Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive genetic disease, arising from mutations in the lipase A, lysosomal acid type (LIPA) gene, characterised by the formation of cholesterol esters (CEs) and triglyceride (TG) storages, primarily in the liver and spleen, but also in the adrenal glands, lymph nodes, gastrointestinal tract, blood vessels, and skeletal muscle tissue. The gene discussed is LIPA; the disease is hereditary disease.