CP and metabolic disease: A broader differential diagnosis for chronic cytolysis was pursued, including infections (hepatitis B virus and hepatitis C virus), autoimmune liver disease (normal values of gamma-globulins and immunoglobin G, negative specific autoantibodies titers), Wilson disease (normal ceruloplasmin level), coeliac disease (negative titers of anti-tissue transglutaminase antibodies), and metabolic diseases (Niemann-Pick, Gaucher, Wolman, glicogenoses, and congenital fructose intolerance) (normal liver and spleen sizes, lack of symptoms for age, normal blood glucose, and no reaction to fructose intake).