AOSD is traditionally characterized by four cardinal symptoms (skin rash, fever > 39°C, leukocytes > 10,000/mm3 with neutrophils > 80%, and arthritis/arthralgia), although many other manifestations may also be present (odynophagia, myalgia/myositis, lymphadenopathy, splenomegaly, serositis, hepatitis, elevated ESR and CRP levels, elevated ferritin, decreased glycosylated ferritin, and coagulation disorders) [5]. The gene discussed is CRP; the disease is Splenomegaly.