TRPML1 interacts with apoptosis-linked gene 2 (ALG2) and JNK-interacting protein 4 (JIP4), thereby promoting lysosomal clustering around the microtubule organizing center in cell models of Parkinson’s disease (Date et al., 2024; Sasazawa et al., 2022; Sasazawa et al., 2024). Here, SPAG9 is linked to Parkinson disease.