It is important to note that CTS5 calculator only takes tumor size, grade, age, and node status into consideration while Predict Breast cancer considers age, DCIS/LCIS status, menopausal status, ER, HER2, Ki67 status, tumor size, grade, and node status for prediction of 10-year disease free survival rate. The gene discussed is MKI67; the disease is ductal breast carcinoma in situ.