NFKB1 and neoplasm: As a result, Morusin suppresses the expression of NF-κB target genes, including pro-inflammatory cytokines (e.g., TNF-α, IL-6), anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL), and oncogenes (e.g., Cyclin D1, MMP-9, and VEGF) that drive tumor growth, proliferation, and metastasis.