Lan et al. (56) reported that cell death was exacerbated in a dose-dependent manner by Quercetin treatment of MIA Paca-2 GEMR cells at 24 h or 48 h, demonstrating that Quercetin can accelerate the death of human PC cells, inhibit the PI3K/Akt/mTOR pathway, and increase the sensitivity of human PC cells to chemical drugs. This evidence concerns the gene AKT1 and pachyonychia congenita.