BCL2 and cancer: To promote cancer cell proliferation, Apigenin not only triggers apoptotic cell death through increased reactive oxygen species (ROS) generation but also orchestrates the downregulation of anti-apoptotic factors such as Bcl-2 and Bcl-xl, accompanied by the upregulation of apoptotic elements such as Bax and Bim (30), which have antiproliferative effects on cancer cells.