The underlying mechanisms may involve the central role of autophagy in regulating immune function, with ULK1 promoting anti-tumor immune responses by enhancing macrophage phagocytic activity, BAG3 inhibiting mast cell activity to weaken the immune response, and DAPK1 down-regulation inhibiting the activity of a variety of immune cells, resulting in difficulties for the immune system to recognize and destroy AML cells, which in turn drives tumor progression. The gene discussed is ULK1; the disease is acute myeloid leukemia.