Among the APANRGs, 5 genes (CCNA1, ENO2, MAGED1, VDAC1, YWHAZ) were down regulated while 19 genes (ANXA1, BTG2, CAPN2, CASP4, CASP7, CD44, GSN, HGF, IL18, IRAK3, LY96, NFKBIA, PDGFRB, PRKX, TAP1, TGFB2, TNFRSF10A, TNFRSF10B, TNFRSF1A) were up regulated in AD. This evidence concerns the gene VDAC1 and Alzheimer disease.