Among the APANRGs, 5 genes (CCNA1, ENO2, MAGED1, VDAC1, YWHAZ) were down regulated while 19 genes (ANXA1, BTG2, CAPN2, CASP4, CASP7, CD44, GSN, HGF, IL18, IRAK3, LY96, NFKBIA, PDGFRB, PRKX, TAP1, TGFB2, TNFRSF10A, TNFRSF10B, TNFRSF1A) were up regulated in AD. Here, CD44 is linked to Alzheimer disease.