Among the APANRGs, 5 genes (CCNA1, ENO2, MAGED1, VDAC1, YWHAZ) were down regulated while 19 genes (ANXA1, BTG2, CAPN2, CASP4, CASP7, CD44, GSN, HGF, IL18, IRAK3, LY96, NFKBIA, PDGFRB, PRKX, TAP1, TGFB2, TNFRSF10A, TNFRSF10B, TNFRSF1A) were up regulated in AD. The gene discussed is CAPN2; the disease is Alzheimer disease.