We then generated the AD risk score (AdRisk) via regression coefficients according to the following formula: AdRisk =-1.2927 + 0.2807 * CAPN2+ 0.0690 * CASP7 + 0.1229 * CD44 + 0.0215 * GSN+0.2170 * HGF - 0.0057 * MAGED1 + 0.1487 *TGFB2 + 0.3159 * TNFRSF10B - 0.6568 * YWHAZ. The gene discussed is CD44; the disease is Alzheimer disease.