TNF-α, through the activation of Tumor Necrosis Factor Receptor 1 (TNFR1) signaling, induces the upregulation of adhesion molecules on blood vessels and can prime and recruit CD8-positive T cells to infiltrate the tumor tissue via activation of Tumor Necrosis Factor Receptor 2 (TNFR2) (61, 69). This evidence concerns the gene CD8A and neoplasm.