AKT1 and neoplasm: Furthermore, autophagy-associated signaling pathways, such as the phosphatidylinositol 3 kinase complex 1 (PI3KC1)-protein kinase B (Akt)-mammalian target of rapamycin complex 1 (mTORC1) pathway, the Ras-Raf-mitogen activated protein kinases (MAPKs) pathway, and the nuclear factor kappa-B (NF-κB) pathway, play a crucial role in fighting against tumor advancement and spread of metastasis.