The collaboration of nobiletin and vorinostat in small cell lung cancer (SCLC) causes autophagy and apoptosis by interfering with the BCL-2 and Beclin-1 complex, releasing Beclin-1 to initiate autophagy and inhibiting PI3K-AKT-mTOR signaling, suggesting nobiletin’s potential as a BH3 mimetic for SCLC combination treatment (321). The gene discussed is AKT1; the disease is small cell lung carcinoma.