The combination of TTA alleles for the TLR7 polymorphisms rs179010 (C/T), rs2074109 (T/C) and rs179009 (A/G) was associated with reduced susceptibility to HIV-1 infection (17), while the CTA haplotype was associated with the progression of chronic hepatitis B (45). The gene discussed is TLR7; the disease is chronic hepatitis B virus infection.