MMP8 and periodontitis: Salvi et al. (2012) similarly reported that IL-1β levels were the same in their study, while MMP-8 levels were greater around the peri-implant region. Although peri-implantitis and periodontitis share similarities in terms of clinical presentation and etiology, significant histopathological distinctions differentiate these two conditions (Berglundh, Zitzmann & Donati, 2011).