In eight studies, Bhagwat et al. (2018), Spasov et al. (2018), Dimitriadis et al. (2018), Li & Fan (2019), Golovanevsky, Eickhoff & Singh (2022), Rahim et al. (2023b); Rahim et al. (2023a) and Lu et al. (2024), they employed MRI in conjunction with clinical assessments, demographic details, and genetic data, particularly the APOe4 marker, from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.