As shown in Figure 4, the AUC values for CBY1 (AUC = 0.800), BCHE (AUC = 0.773), EDEM3 (AUC = 0.768), and FKBP10 (AUC = 0.760) exceeded 0.75, indicating a good predictive ability for COPD. Here, EDEM3 is linked to chronic obstructive pulmonary disease.