This study compared the expression levels of AGR3, BCHE, CBY1, CHRM3, DDHD1, DMPK, EDEM3, EDN1, HSPA2, KPNA2, LGALS3, MAOB, PIK3CA, PURA, and TMCC1 between COPD and control groups and evaluated their predictive abilities. This evidence concerns the gene HSPA2 and chronic obstructive pulmonary disease.