Diabetes is also characterized by platelet hyperreactivity (10) resulting from hyperglycemia, which induces the expression of multiple platelet activation receptors [glycoprotein (GP) Ib, GP IIb/IIIa, and P2Y12] and glycation of platelet surface proteins, leading to insulin resistance, reduced membrane fluidity, and higher thromboxane A2 production (11). This evidence concerns the gene P2RY12 and diabetes mellitus.