Furthermore, the influence of gene expression with greater absolution value of risk coefficients on the prognosis of glioma patients was investigated, and the findings revealed that TNFRSF12A, NBIRC5, and TLR3 were prognostic risk factors, whereas ANGPTL2 was a protective factor for prognosis in glioma patients (Fig. S2A–E). Here, TLR3 is linked to central nervous system cancer.