,2 Single nucleotide polymorphism (SNP) in the non-coding region, especially the promoter region, might correlate well with plasma BNP levels, and potentially affect the susceptibility of DCM-HF, through interacting with transcription factor and regulating natriuretic peptide B (NPPB) gene transcription.3 Here, NPPB is linked to familial dilated cardiomyopathy.