LEP and endometriosis: Enriched environments (more space to move about, increased physical activity and social interactions) suppresses the development of endometriosis in mice by attenuating adrenergic signalling, enhancing autophagy, and reducing leptin levels.45 Extrapolating this to humans, Flores et al46 reported a significant reduction in pelvic pain, perceived stress and improved mood and emotional wellbeing in endometriosis patients who were randomised to outdoor physical activities such group yoga to optimise environmental enrichment as compared to controls.