KIT and myeloproliferative neoplasm: In addition to KIT mutation, patients with SM-AHN often harbor an additional genetic defect correlating to a myeloid neoplasm, such as chronic myelomonocytic leukemia (CMML), myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), myeloproliferative neoplasm (MPN), and chronic eosinophilic leukemia (CEL) [2, 6].