SLC12A2 and dementia: Members of the plasma membrane cation-chloride cotransporter (CCC) family, such as the neuron-specific K+/Cl− transporter KCC2 and the ubiquitously expressed Na+-K+-2Cl− cotransporter NKCC1 (encoded by the Slc12a2 gene), are increasingly the focus of research in central nervous system (CNS) diseases, including neuropsychiatric disorders, epilepsy, stroke, and dementia (Tóth et al., 2022).