Compared to WT mice, TLR2/4-deficient mice exhibit lower levels of these inflammatory cytokines, smaller infarct volumes, milder neuroinflammation, and higher neuronal survival rates in the ischemic hemisphere after cerebral ischemia–reperfusion injury (Tajalli-Nezhad et al., 2019; Qiu et al., 2019). Here, TLR2 is linked to brain ischemia.