Members of the plasma membrane cation-chloride cotransporter (CCC) family, such as the neuron-specific K+/Cl− transporter KCC2 and the ubiquitously expressed Na+-K+-2Cl− cotransporter NKCC1 (encoded by the Slc12a2 gene), are increasingly the focus of research in central nervous system (CNS) diseases, including neuropsychiatric disorders, epilepsy, stroke, and dementia (Tóth et al., 2022). Here, SLC12A2 is linked to Stroke.