MAPT and Cognitive impairment: Additionally, MHs (Schneider et al., 2024), current smoking status (Terravecchia et al., 2021), cognitive impairment (Lenka et al., 2023), anxiety (Factor et al., 2017), gastrointestinal autonomic dysfunction, RBD, the Aβ42/total tau ratio (Chen et al., 2024), and grey matter volume within specific structural covariance networks (Knolle et al., 2023) are independent predictors of PDP.