We observed an evolution of keywords from “dopaminergic psychosis” (e.g., levodopa, drug-induced psychosis, dopaminergic-induced hallucinations) and atypical antipsychotics (AAPs) (e.g., olanzapine, clozapine, risperidone) to “5-HT2A inverse agonist(s),” “pimavanserin,” and “Parkinson’s disease psychosis (PDP),” reflecting a shift in research focus from AAPs to novel anti-PDP drugs. The gene discussed is HTR2A; the disease is psychotic disorder.