Berberine derived from the plants Argemone Mexicana, Berberis aquifolium, Berberis vulgaris, improves cognitive and motor skills and reduces levels of mutant protein huntingtin (Htt), NF-κB, α, IL 6, IL-8 and oxidative stress caused by ROS and RNS in HD patients (Singh et al., 2022). This evidence concerns the gene NFKB1 and Huntington disease.