We compared the values of the SPISE index, using both the 75th percentile of HOMA-IR (Table 5) and the 99.2th percentile (Table 5) as insulin resistance cut-off; in both cases we obtained a significantly lower SPISE value in patients categorized as insulin resistant, in all Tanner groups (HOMA-IR > 75th percentile; Tanner Stage 1: p value 0.017; Tanner Stages 2-3-4: p value 0.010; Tanner Stage 5: p value < 0.0001) (HOMA-IR > 99.2th percentile; Tanner Stage 1: p value 0.08; Tanner Stages 2-3-4: p value < 0.0001; Tanner Stage 5: p value 0.008). The gene discussed is INS; the disease is Insulin resistance.