INS and Insulin resistance: Another widely used index of insulin resistance is the HOMA-IR [fasting plasma insulin in microU/ml x fasting plasma glucose (FPG) in mmol/l)/22.5]; we defined percentiles in a cohort of normal children and adolescents, and considered patients with HOMA-IR > 75th percentile or > 99.2th percentile as potentially being at higher risk of insulin resistance (46).