INS and Insulin resistance: Based on our previous reported findings that a total sum of insulin ≥ 535 microU/ml during OGTT had a high specificity in identifying insulin-resistance (27), we compared the SPISE values, maintaining the division into pubertal stages, in patients classified as insulin resistant (i.e. a sum of insulin at five points OGTT ≥ 535 microU/ml, compared to patients with a sum of insulin <535 microU/ml).