On an atherogenic Western-type diet (WD), male and female mice with induced global LpL deficiency (iLpl−/−) and LDLR knockdown (Ldlrkd) developed hypertriglyceridemia and elevated cholesterol levels; all the increased cholesterol was in chylomicrons or large VLDL. This evidence concerns the gene LDLR and hyperinsulinemic hypoglycemia, familial, 4.