To determine if aggregate accumulation occurs in the hippocampus of symptomatic SCA7 mice, we performed IHC with an anti-ataxin-7 antibody, and noted prominent aggregate formation in neurons in the dentate gyrus of the hippocampus (Supplementary Figure S3), confirming pathological involvement of this brain region in this SCA7 mouse model. The gene discussed is ATXN7; the disease is spinocerebellar ataxia 7.