When we quantified Purkinje cell nuclear membrane morphology in symptomatic SCA7 266 mice and non-transgenic, age-matched wild-type (WT) littermate controls by counting the number of Purkinje cells, marked by calbindin, with nuclear membrane convolutions (Figure 1a), we did not observe a significant difference, as 86% of SCA7 266Q and 82% of WT Purkinje cells displayed such nuclear membrane convolutions (Figure 1b). The gene discussed is CALB1; the disease is spinocerebellar ataxia 7.