Similarly, ultrastructural analysis of Neuro2a cells transfected with mutant profilin-1, which can cause ALS, revealed severe defects in the structure of the nucleus, with frequent folds, invaginations, and protrusions that are not observed in cells expressing normal profilin-1 (Giampetruzzi et al., 2019). Here, PFN1 is linked to amyotrophic lateral sclerosis.