Immunostaining of iPSC-derived cortical neurons from frontotemporal dementia (FTD) patients with autosomal dominant mutations in the MAPT gene, encoding tau protein, uncovered marked differences in nuclear morphology between non-demented controls and tau mutant neurons, with the presence of large folds or invaginations of the Lamin B1-positive inner nuclear lamina (Paonessa et al., 2019). The gene discussed is LMNB1; the disease is frontotemporal dementia.