We found that HJURP was significantly positively correlated with the activation of cell cycle (R = 0.93, p < 0.001), DNA damage (R = 0.73, p < 0.001), DNA repair (R = 0.73, p < 0.001), cell proliferation (R = 0.44, p < 0.001), hypoxia (R = 0.26, p < 0.001), invasion (R = 0.28, p < 0.001), and metastasis (R = 0.17, p < 0.001) pathways, and showed a negative correlation with tumor differentiation (R = −0.16, p < 0.001) and stemness (R = −0.22, p < 0.001). Here, HJURP is linked to neoplasm.