However, only higher SBP was the independent predictor of lower 1‐year CV mortality (HR: 0.86, 95%: 0.71−0.97, p = 0.029) in a multivariate analysis that included age, gender, diabetes, obesity, type of MR (functional vs. structural), use of beta‐blockers, ACEI/ARB, ARNI, aldosterone antagonists, GFR, NT‐pro‐BNP, LVEDD, LVEF, MR severity, EuroSCORE II, and systemic vascular resistance. This evidence concerns the gene NPPB and obesity due to melanocortin 4 receptor deficiency.