Furthermore, in a study of Australian patients with RA or psoriatic arthritis, the use of methotrexate was associated with an increased risk of nonmelanoma skin cancer (NMSC) [16], while a systematic review and meta‐analysis of patients with RA suggested that use of tumor necrosis factor inhibitors (TNFi) was also associated with an increased risk of NMSC [17]. The gene discussed is TNF; the disease is rheumatoid arthritis.