Activation of intracellular signaling pathways such as the mitogen‐activated protein kinase pathway, phosphatidylinositol 3‐kinase/protein kinase B/mammalian target of rapamycin pathway, and phospholipase C γ pathway by BDNF can all potentially enhance the growth, survival, proliferation, and migration of cancer cells, influencing cancer development. This evidence concerns the gene BDNF and cancer.