Also of note, a specific mutation in the PLAUR gene (rs4760), implicated in elevated levels of suPAR and has been associated with an increased risk of schizophrenia in males, converging with the sex-dependent increased risk of schizophrenia with heavy cannabis use (Hjorthøj et al., 2023; Karagyaur et al., 2024). The gene discussed is PLAUR; the disease is schizophrenia.