In addition, as lipid metabolism disorder and cerebral ischemic stroke were reported to alter epigenetic pattern in brain, the remodeling of Mef2c transcriptional network could explain Mef2c's mediating neuronal cell death and aggravating neurological deficits following ischemic stroke with concomitant hyperlipidemia [55, 56, 57]. Here, MEF2C is linked to ischemic stroke.