To further evaluate the impact of neuronal specific Mef2c depletion on the ischemic brain injury and post‐stroke neurological functions, we subjected HFD‐treated Mef2cfl/fl or Emx1CreMef2cfl/fl mice to MCAO, and examined the brain injury with MAP2 and IgG double staining and behavioral tests. Here, MAP2 is linked to stroke disorder.