To investigate whether HFD aggravated ischemic injury and stroke outcome, we stained brain sections with immunoglobulin G (IgG) and microtubule‐associated protein 2 (MAP2), and found that the infarct volume of HFD‐treated mice was significantly increased compared to that of ND‐treated mice 3 days following MCAO (Figure 1H). Here, MAP2 is linked to stroke disorder.