CRP and necrotizing enterocolitis: Consistent with the results observed with acetate treatment in these models, both GLPG0974 administration and GPR41 knockout abolished the protective effects of L. gasseri FWJL-4 on NEC, as evidenced by reduced small intestine length (Figure 7a), decreased survival rates (Figure 7b), weight loss (Figure 7c), increased DAI (Figure 7d), and elevated serum CRP and SAA levels (Figure 7e,f).