These results showed that KLF7 drove the progression of HCC through the intake of Trp, while whether KLF7‐mediated trp import contributed to HCC development through the metabolism pathway of serotonin and the in vivo role of KLF7‐mediated trp metabolism in HCC metastasis should be determined in the follow up study. The gene discussed is KLF7; the disease is hepatocellular carcinoma.