CD4 and neoplasm: Recent studies have suggested mitochondria-related characteristics of tumors were associated with the tumor microenvironment.29,30 The densities of CD4 cells were similar in Mito-high and Mito-low tumors (p = 0.95) [Fig. 2a], while the density of CD8 cells was significantly higher in the former than in the latter (median 988.2/m2 vs. 648.5/m2; p = 0.017) [Fig. 2a].