For instance, three hub genes, CDH5, ACTN1, and GNA12, were common in MDD suicide and MDD non-suicide subjects, which could activate or repress an array of gene sets within the network (CAT, BAIAP2, NCKIPSD, RAPTOR, HDAC4, ADAMTS17, HSP90AA1, PSMA7, DAAM, LRP1) with specific roles to develop endophenotypes associated with depression and suicide [62, 67]. Here, ACTN1 is linked to major depressive disorder.