HDAC4 and Cognitive impairment: For example, CAT is involved in innate immunity, BAIAP2 in neurite growth and maintenance of dendritic spines, NCKIPSD in modulation of synaptic activity in neurons, RAPTOR in excitatory neuronal activity, ADAMTS in neuronal plasticity and cognitive impairment, PSMA7 in inflammatory immune response, DAAM in axonal growth cone formation and regeneration, HDAC4 in activity-dependent synaptic transmission, and HSP90AA1 in HPA axis-related neuroendocrine abnormalities [68–72].