For instance, three hub genes, CDH5, ACTN1, and GNA12, were common in MDD suicide and MDD non-suicide subjects, which could activate or repress an array of gene sets within the network (CAT, BAIAP2, NCKIPSD, RAPTOR, HDAC4, ADAMTS17, HSP90AA1, PSMA7, DAAM, LRP1) with specific roles to develop endophenotypes associated with depression and suicide [62, 67]. This evidence concerns the gene LRP1 and major depressive disorder.