RPTOR and major depressive disorder: For instance, three hub genes, CDH5, ACTN1, and GNA12, were common in MDD suicide and MDD non-suicide subjects, which could activate or repress an array of gene sets within the network (CAT, BAIAP2, NCKIPSD, RAPTOR, HDAC4, ADAMTS17, HSP90AA1, PSMA7, DAAM, LRP1) with specific roles to develop endophenotypes associated with depression and suicide [62, 67].