Besides, transfecting with Hsp90α domain deletion plasmid (ΔN or ΔC) in HCC cells led to a decline of FASN, and a corresponding decrease in lipid accumulation was also observed, indicating that these two terminal domains were both indispensable for Hsp90α to regulate FASN-related lipid synthesis. The gene discussed is FASN; the disease is hepatocellular carcinoma.