Our data suggested that Hsp90α interacted with LXRα to prevent its degradation via proteasome pathway, thus ensuring the bindings of LXRα on of both SREBF1 promoter region and FASN promoter region and promoting the transcription of SREBF1 and FASN. Moreover, apart from Hsp90α, this study found that Hsp90β also contributed to the lipid accumulation of HCC through the LXRα/SREBP1/FASN axis, but the specific mechanism of this similar systemic effect remains to be further explored. The gene discussed is HSP90AB1; the disease is hepatocellular carcinoma.