All these data revealed a new mechanism that Hsp90α promoted lipid accumulation in HCC cells by maintaining FASN protein stability and upregulating FASN mRNA transcription through LXRα/SREBP1 axis, thus creating a favorable condition for survival and proliferation of HCC cells, providing a new strategy for the clinical treatment of HCC in lipid metabolism related pathway. The gene discussed is SREBF1; the disease is hepatocellular carcinoma.