For example, the TF SPECIAL AT-RICH SEQUENCE BINDING PROTEIN-1 (SATB1), a HD TF found in humans that regulates over 1000 genes and controls transcription in various biological processes, such as switching of fetal globin genes, metastasis of breast cancer, and differentiation of embryonic stem cells, has been assessed using ITC [156]. The gene discussed is SATB1; the disease is breast cancer.