ALDH2 and cancer: BRCA2 p.E1953∗ (c.5857G>T; dbSNP: rs80358814), TP53 p.V272M (c.814G>A; dbSNP: rs121912657), and ALDH2 p.E504K (c.1510G>A; dbSNP: rs671) are cancer-associated SNVs at PAM+1, PAM+3, and PAM+5, respectively, the last of which is claimed to be the most common human point mutation25 (Figures 6A, 6C, and 6E).