This is in line with previous studies that demonstrated a decrease in intima–media thickness under biologic treatment of psoriasis—albeit this was also observed in patients treated with methotrexate.37, 38, 39 In line, randomized controlled trials demonstrated that IL12/23i reduce aortic vascular inflammation, while TNFi and phototherapy reduce CRP and IL-6 serum concentration in patients with psoriasis.40 This evidence concerns the gene CRP and psoriasis.