CBS and malignant colon neoplasm: Also, correlation studies, using various publicly available cancer databases, should be conducted to test if correlations exist between the regulation of various H2S degradation pathways and clinical outcomes in various forms of cancer (such studies, with respect to H2S synthesizing enzymes, already exist and indicate that in various forms of cancer, e.g. ovarian or colon cancer, upregulation of CBS correlates with a poor clinical prognosis).