For instance, Lu et al. (2018) demonstrated that the enhancer of zeste homolog 2 (EZH2), a histone-lysine methyltransferase in the polycomb repressive complex 2 (PRC2), inhibited the transcription of the GDF15 gene by modifying the H3K27me3 site in human NSCLC cell lines and that this promoted tumorigenesis in mice. This evidence concerns the gene EZH2 and non-small cell lung carcinoma.