TMEM258 and bipolar disorder: This suggest that miR-1908-5p likely contributes to bipolar disorder and major depression through its effect on FADS1 mRNA expression but acts independently of TMEM258. Similarly, miR-499a-5p is an independent causal mediator from GGT7 and EDEM2 in bipolar disorder (Extended Data Figs. 4 and 5 and Supplementary Table 17).