EPAS1 and benign colon neoplasm: We also found that EPAS1 (TIBC) was inversely associated with hypertension and that SLC25A28 (ferritin) was positively associated with colorectal cancer and benign neoplasm of colon; however, no other iron-related loci were associated and colocalized with these diseases, suggesting that these effects may be driven by horizontal pleiotropy.