To determine whether the overexpression of GRIM-19 mitigates SSc, the pFLAG-CMV-5a R12 mGRIM-19 plasmid was intravenously injected once a week for 5 weeks into bleomycin-induced SSc mice, and disease severity was evaluated in comparison with that in control mice (Fig. 2b). Here, NDUFA13 is linked to systemic sclerosis.