Analysis of mitochondrial fission– and fusion–related proteins in bafilomycin-resistant rhabdomyosarcoma cells (Fig 4A and C and S5) and osteosarcoma cells (Figs 4B and C and S5) exposed to IC50 doses of chemotherapy drugs (as detailed in Fig S1) revealed that the drug-induced modulation of DRP1 depended on the initial status of DRP1. Here, DNM1L is linked to osteosarcoma.