Unexpectedly, we observed preferential down-regulation of these mitochondrial stress sensors in drug-exposed sarcoma cells (Fig S6), suggesting that OMA1 and YME1L1 may have OPA1 processing–independent functions in sarcoma chemotherapy adaptation; similarly, OMA1 was recently reported to induce a metabolic shift upon DNA damage (52). This evidence concerns the gene OPA1 and sarcoma.