Characterization of single-cell–derived clones from DRP1 knockdown (shDRP1) and control (shCTRL) cells confirmed the depletion of DRP1 and demonstrated a marked decrease in its activating phosphorylation form in both rhabdomyosarcoma and osteosarcoma models (Figs 5A and E and S7). The gene discussed is DNM1L; the disease is osteosarcoma.