Similar compensatory mechanisms might also be adopted by sarcoma cells, as evidenced by the up-regulation of the DRP1 adaptor proteins MFF and FIS1 in DRP1-depleted rhabdomyosarcoma RD cells (Figs 6B and S17), further suggesting that therapies targeting DRP1 for sarcoma may be likely to fail. Here, MFF is linked to rhabdomyosarcoma.