Interestingly, post-therapy osteosarcoma Saos-2 cells showed up-regulated levels of both mitochondrial fission– and fusion–related proteins despite maintaining relatively low mitochondrial mass, as assessed by the expression of the translocase of outer mitochondrial membrane 20 (TOMM20), which serves as a proxy for mitochondrial content. The gene discussed is TOMM20; the disease is osteosarcoma.