DNM1L and sarcoma: Since sarcoma survival was stratified by DRP1 expression (Fig 1B) and up-regulated DRP1-activating phosphorylation at S616 was associated with the post-therapy state (Fig 1C and D), with exposure to chemotherapeutics further increasing this phosphorylation (Figs 2C and D and 4A–C), we hypothesized that DRP1 activity is involved in the mechanism that protects sarcoma cells against chemotherapy-induced stress.