Similarly, when both the AgeAccelDiff and IEAA were categorized into accelerated age (ACC, positive deviation of DNAm age from age) and decelerated age (DCC, negative deviation of DNAm age from age), the women with ACC had shorter cancer-free intervals than those with DCC in the overall BC and the ER/PR–positive and HER2/neu–negative groups. This evidence concerns the gene ESR1 and breast cancer.