Single nucleotide polymorphisms (SNPs) in genes like MTHFR, COMT, and FUT2 significantly influence nutrient metabolism, hormonal regulation, and inflammatory responses.8, 9, 10 ML algorithms allow for the prediction of how variations in these genes impact susceptibility to conditions such as cardiovascular disease, metabolic disorders, and mood disturbances during perimenopause. This evidence concerns the gene COMT and Other metabolic disease.