INS and Hyperglycemia: New or worsening hyperglycaemia was defined as fasting plasma glucose of 100 mg/dL (5.5 mmol/L) or greater, random plasma glucose of 140 mg/dL (7.8 mmol/L) or greater, an increase of 20% or more in daily doses of insulin, any increase in oral antidiabetic drugs, initiation of one or more antidiabetic therapeutic principles