To define the molecular changes driving resistance to NK cells, we compared the transcriptomic profiles of B-ALL cells after co-culture with WT and Prf1-/- (day 14, Figures 4I&J and Supplementary S9A&B) or Ifng-/- NK cells (day 17, Figures 4K&L and Supplementary S9C&D and day 32, Figures Supplementary S9E-H). The gene discussed is PRF1; the disease is acute lymphoblastic leukemia.