Given that the Gpn family proteins were initially characterized in chromosomal instability (CIN) mutants [28], it is plausible that PAB1, CDC5, and RGS2 play crucial roles in regulating Gpn1 and Gpn2 activities that are essential for maintaining genome stability and transcriptional regulation. The gene discussed is CDC5L; the disease is cervical squamous intraepithelial neoplasia.