TRPC6 and chronic kidney disease: As shown in Figure 7D, in the TRPC6-cKD male mice, the sucrose preference was significantly reduced (7Di, 74.52±2.00%, N=10 for TRPC6-cKD, vs 85.87±1.85%, N=10 for control, Two-sample t-test, t=4.172, df=18, 95% CI: –17.07 to –5.634, p=0.0006), the immobility time in the Tail suspension test was significantly lengthened (7Dii, 142.00±4.66 s vs 121.40±3.94 s, Two-sample t-test, t=3.377, df=18, 95% CI: 7.785–33.41, p=0.0034).